Quisinostat ( (JNJ-26481585) )

Catalog No. M16360 CAS No. 875320-29-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

Quisinostat
Note

Research use only, not for human use.
Brief Description

Quisinostat (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11.
Description

Quisinostat (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2.
Synonyms

(JNJ-26481585)
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC8
Research Area

Cancer
Indication

——

CAS Number

875320-29-9
Formula Weight

394.48
Molecular Formula

C21H26N6O2
Purity

>98%(HPLC)
Solubility

DMSO:79 mg/mL (200.26 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)
SMILES

O=C(C1=CN=C(N2CCC(CNCC3=CN(C)C4=C3C=CC=C4)CC2)N=C1)NO
Chemical Name

N-hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)methyl)piperidin-1-yl)pyrimidine-5-carboxamide

1.Arts J, et al. Clin Cancer Res, 2009, 15(22), 6841-685

Calculator

molnova catalog